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Studies have shown that male smokers have 23% lower sperm concentration compared to non-smokers

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They hypothesized that the diminished osteogenic ability of smokers MSCs results from the detrimental effects of cigarette smoke on the miRNA-1305/Runt-related transcription factor 2 (RUNX2) axis, given that miRNA-1305 regulates RUNX2 activity, which is crucial for osteoblast development 62